Researchers seeking a reliable BZP research chemical for their work need a supplier that understands the demands of professional laboratory environments. CityChems provides high-purity benzylpiperazine (BZP) to researchers across Europe, with a focus on quality, transparency, and service.
Benzylpiperazine, commonly referred to as BZP, is a synthetic piperazine derivative classified as a novel psychoactive substance (NPS) under the systematic categorization adopted by the United Nations Office on Drugs and Crime . First synthesized in the 1940s, BZP has since become a compound of interest in forensic toxicology, neuropharmacology, and analytical chemistry . It is primarily intended as an analytical reference standard for forensic and research applications .
BZP acts as a monoamine transporter ligand, with a particular affinity for stimulating dopamine release via the dopamine transporter . Studies have demonstrated that BZP elevates both dopamine and serotonin levels in vivo, producing a pattern that has been the subject of considerable scientific investigation . In rat brain synaptosome release assays, BZP exhibits a clear preference for dopaminergic pathways compared to serotonergic pathways, distinguishing it from other piperazine analogs .
Product Specifications
- Name: 1-Benzylpiperazine (BZP)
- Synonyms: N-Benzylpiperazine
- CAS Number: 2759-28-6
- Molecular Formula: C₁₁H₁₆N₂
- Molecular Weight: 176.26 g/mol
- Appearance: White to off-white crystalline powder
- Purity: ≥98%
- Storage: Powder stable for 3 years at -20°C
- Solubility: Soluble in DMSO and DMF (30 mg/mL)
Research Applications
BZP is a valuable tool for researchers investigating monoamine transporter pharmacology and the neurochemical basis of stimulant effects. Its mechanism of action—preferential dopamine release via the dopamine transporter and norepinephrine transporter blockade—makes it relevant to several research domains:
- Forensic Toxicology: BZP is widely used as a certified reference standard for LC-MS and GC-MS testing methods in urine drug screening . Analytical reference materials with ≥98% purity enable precise calibration curves for defensible quantitative data .
- Neuropharmacology: Researchers study BZP to understand monoamine transporter systems and the neurochemical basis of stimulant effects .
- ADME Profiling: In silico studies have characterized BZP’s absorption, distribution, metabolism, and excretion profile. Key findings include high oral bioavailability (96.7%), moderate volume of distribution (2.6 L/kg), and rapid clearance (10.81 mL/min/kg) . BZP is predicted to be primarily metabolized by CYP2D6, with eight metabolites identified .
- Toxicological Assessment: Studies have investigated the cellular toxicity of piperazine derivatives, including mitochondrial dysfunction and cytoskeletal changes in neuronal models .
Why Choose CityChems for BZP Research Chemical?
When you buy research chemicals BZP from CityChems, you benefit from:
- High Purity Standards: Our BZP powder meets strict purity specifications (≥98%) to support accurate and reproducible research .
- European Location: Our presence in Europe simplifies logistics and reduces delivery times for customers across the continent.
- Professional Service: Our support team is available to answer your questions and assist with your orders, ensuring a smooth purchasing process.
- Secure Platform: We provide a protected online environment to safeguard your data and transactions.
- Transparent Communication: We provide clear, factual information about our products and services without exaggeration.
Frequently Asked Questions
1. What is BZP research chemical?
BZP (1-Benzylpiperazine) is a synthetic piperazine derivative classified as an analytical reference standard for forensic and research applications . It acts as a monoamine transporter ligand and has been studied for its pharmacological profile .
2. What is the purity of your BZP powder?
We provide BZP powder with ≥98% purity, suitable for research and forensic applications. This level of purity enables precise LC-MS and GC-MS calibration curves .
3. What are the storage conditions for BZP?
For long-term stability, BZP powder should be stored at -20°C, protected from moisture and light. The powder is stable for 3 years under these conditions .
4. Is BZP soluble in common laboratory solvents?
BZP is soluble in DMSO and DMF at concentrations up to 30 mg/mL . It has limited solubility in water and is typically prepared in organic solvents for laboratory applications.
5. What are the applications of BZP in research?
BZP is used in forensic toxicology as an analytical reference standard, in neuropharmacology to study monoamine transporter systems, and in method development for detecting piperazine derivatives .
6. Is BZP a controlled substance?
The legal status of BZP varies by country. It is classified as a stimulant with recognized abuse potential in some jurisdictions . It is the responsibility of each researcher to verify the regulations in their country. CityChems supplies BZP exclusively for research and forensic applications.
7. How does BZP differ from other piperazine derivatives?
BZP has a distinct pharmacological profile from other piperazines such as TFMPP. While BZP acts primarily through dopamine and norepinephrine pathways, TFMPP acts predominantly via serotonin receptors . These differences make product selection essential for research.
8. What do studies reveal about BZP’s pharmacokinetics?
In silico studies indicate that BZP has high oral bioavailability (96.7%), moderate volume of distribution (2.6 L/kg), and rapid clearance (10.81 mL/min/kg). It is primarily metabolized by CYP2D6, with eight metabolites predicted .